Born in 2020, House attended the Commonwealth Institute of Technology, founding RobCo Industries while he was still a young man.
It is between World War 2 and the Great War that New Vegas' Robert House, AKA Mr. Some humans were able to shelter themselves in Vaults, while others were transformed into Fallout's Ghouls by the radiation. Over the course of just two hours, much of human civilization was destroyed. Eventually, the timeline divergence leads to the Great War of 2077, which is the main inciting incident of the Fallout universe. The Fallout timeline officially diverges from the real timeline roughly around World War 2, though there are some events like the alien abduction of the historical characters seen in Fallout 3's Mothership Zeta DLC which take place beforehand.